Formulation and evaluation of a medicated roll-on containing ibuprofen and magnesium chloride

Abstract

Topical drug delivery has emerged as an effective approach for managing localised pain while minimising the systemic adverse effects associated with oral therapy. This study focuses on the development and evaluation of a medicated roll-on containing ibuprofen and magnesium chloride for the treatment of musculoskeletal pain and inflammation. The formulation was designed using suitable excipients to improve drug solubility, stability, skin compatibility and transdermal penetration. Ibuprofen provides anti-inflammatory and analgesic effects, whereas magnesium chloride promotes muscle relaxation and supports pain relief. The prepared formulation was evaluated for key physicochemical properties, including pH, viscosity, spreadability, drug content, and in vitro drug release. Stability and compatibility studies were also carried out to ensure product quality and performance. The findings indicate that the formulated roll-on is a promising, convenient, and patient-friendly topical system for localised pain management.

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Cite this article

Sujal Panchal. FORMULATION AND EVALUATION OF A MEDICATED ROLL-ON CONTAINING IBUPROFEN AND MAGNESIUM CHLORIDE. ClinSphere Journals. 2026;1(1). https://doi.org/10.5281/zenodo.22854313

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